Director, Forecasting (Lung)

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: Reporting to the Senior Director, U.S. Forecasting, the Director, U.S. Forecasting will be responsible for developing and executing forecasting models and analyses that support product strategy, performance management, and operational planning. This role focuses on building and maintaining short-term demand forecasts and patient-based models across U.S. oncology assets, enabling manufacturing, supply chain, and commercial decision-making. The Director will partner closely with cross-functional stakeholders to align on forecast inputs, assumptions, and outputs, while ensuring high-quality, timely deliverables. As a key contributor within the U.S. Forecasting function, this individual will execute forecasting processes in alignment with the broader U.S. forecasting strategy and contribute to ongoing improvements in forecasting capabilities, tools, and data integration. This position is based at our Redwood City, CA headquarters, with flexibility for remote candidates willing to travel regularly to the office. Responsibilities include: Develop, maintain, and refine short-term demand forecasts across U.S. oncology products, including SKU-, dose-, and channel-level projections to support supply chain and commercial planning. Build and manage patient-based forecasting models incorporating oncology-specific dynamics such as incidence, biomarker segmentation, lines of therapy, treatment duration, and market evolution. Conduct scenario, sensitivity, and risk analyses to evaluate key business drivers and inform near-term decision-making. Translate complex data, assumptions, and model outputs into clear, actionable insights to support launch planning, performance tracking, and operational readiness. Partner cross-functionally with Commercial, Finance, Market Access, Medical Affairs, Supply Chain, and Manufacturing to gather inputs, validate assumptions, and ensure alignment on forecast outputs. Support development of production and inventory strategies by providing accurate and timely forecast updates and analyses. Integrate real-world data, secondary data sources (e.g., IQVIA), and competitive intelligence into forecasting models to enhance accuracy and responsiveness. Execute forecasting activities in alignment with U.S. Forecasting strategy and methodologies established by senior leadership, ensuring consistency and rigor. Support enhancements to forecasting processes, tools, and data infrastructure, including model standardization and automation initiatives. Maintain clear and transparent documentation of forecasting methodologies, assumptions, and data sources. Manage external vendors and data partners to ensure delivery of high-quality inputs and analyses. Escalate key risks, assumptions, and forecast variances to senior leadership with clear summaries and recommendations. Stay current on Revolution Medicines’ portfolio, competitive landscape, and evolving oncology market dynamics. Required Skills, Experience and Education: Bachelor’s degree in business, life sciences, statistics, or economics required; advanced degree (MBA, MS, MPH, or PhD) preferred. 8+ years of experience in pharmaceutical, biotechnology, or consulting roles, including at least 5 years in forecasting, analytics, or demand planning. Demonstrated experience building and maintaining patient-based and/or demand-based forecasting models supporting commercial and operational decision-making. Strong understanding of forecasting methodologies, including patient-based modeling, scenario analysis, and data-driven forecasting approaches. Experience working with oncology data and/or oncology markets preferred. Proficiency in analytics and visualization tools (e.g., Excel, Tableau, Power BI or equivalent). Experience working with secondary data sources (e.g., IQVIA) and integrating multiple data streams into forecasting models. Strong analytical and problem-solving skills, with the ability to synthesize complex data into actionable insights. Demonstrated ability to collaborate effectively across cross-functional teams and contribute to decision-making processes. Strong organizational skills and attention to detail, with the ability to manage multiple priorities in a fast-paced environment. Effective communication skills, including the ability to clearly present analyses and insights to diverse stakeholders. Preferred Skills: Experience in oncology forecasting, including patient flow modeling and treatment dynamics. Experience supporting product launches or pre-commercial forecasting. Familiarity with supply chain or manufacturing planning processes. Experience working in a fast-paced, growth-stage biotechnology organization. Experience managing vendors or external analytics partners. #LI-Hybrid #LI-SS2 The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training. Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities. Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status. Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy . For additional information, please contact [email protected] . Base Pay Salary Range $211,000 — $264,000 USD We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message. Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official @revmed.com email address. If you believe you’ve been contacted by someone impersonating a Revolution Medicines recruiter, please report it to [email protected] so we can share these impersonations with our IT team for tracking and awareness.