Translational Scientist (DMPK & Safety)

About Healx Healx is an AI-powered tech bio company redesigning drug discovery. With over 10,000 rare diseases affecting 400 million people globally – and 90% lacking approved treatments – our mission is to pioneer a new generation of drug discovery to bring treatments to patients faster. We combine data, artificial intelligence and deep pharmacology expertise to develop therapies more efficiently and cost-effectively than traditional approaches. Diversity and inclusion sit at the heart of our mission to help people with rare diseases. We believe that building and empowering a diverse team is critical to achieving this goal. We welcome applications from people of all backgrounds and experiences. Below, we outline the qualities we believe will help you succeed in this role. However, we recognise that skills can be transferable. If you're excited by our mission and values but don't meet every requirement, we still encourage you to apply. Our Values Care for rare – Patients are at the heart of what we do Grow as individuals – We are continuous learners, always developing our expertise Win as a team – We foster inclusion, celebrate successes, and learn together Innovate and deliver – We move quickly, take thoughtful risks, and uphold high standards The Role We are seeking a Translational Scientist (DMPK & Safety) to play a critical role in bridging AI-driven drug predictions with clinical reality. This is a drug-centric, highly collaborative role where you will not only generate and interpret data but also shape the non-clinical path to the clinic. You will sit within the pharmacology team while working closely with our tech, curation, and clinical teams to translate computational predictions into viable therapeutic candidates. We are looking for someone with strong DMPK expertise who is eager to expand into a broader translational role – contributing strategically across the drug discovery lifecycle. We encourage you to provide a covering letter to explain why you think you’d be successful in this role. Key Responsibilities Study Design & Oversight: Provide technical peer review for DMPK and safety in vitro and in vivo study designs. You’ll refine protocols to ensure we generate "gold standard," actionable data. CRO Management: Act as the technical lead for our external research partners and CROs. Data Reporting: Synthesise chemical, pharmacological, and PK data into high-quality summary reports and preclinical dossiers. Drug-Centric Translation: Contribute technical expertise to help the team generate and evolve an appropriate Target Product Profile (TPP), ensuring discovery programmes are aligned to the long-term patient needs. Strategic Triage: Support the Project Leader/Pharmacology team in reviewing AI-generated drug predictions using your DMPK and safety knowledge to identify the candidates most likely to succeed in the clinic. Cross-Functional Connectivity: Bridge the gap between preclinical, tech, clinical, and commercial teams, providing insights on safety liabilities, drug exposure, and population suitability. AI Impact: Proactively seek opportunities to use AI and advanced computational tools to generate and refine DMPK and safety knowledge. You will know you are successful when Integrated Decision-Making : You are a trusted partner across teams, aligning scientific and strategic perspectives. High-Quality External Delivery: CROs and partners consistently deliver strong, actionable data under your guidance. Knowledge Sharing: You contribute to a collaborative environment where decisions are grounded in robust DMPK and safety insights. What we are looking for Experience in DMPK within biotech or pharma. Strong expertise in DMPK modelling (e.g. Phoenix WinNonlin or similar tools). Ability to integrate diverse datasets into clear scientific narratives. Experience using Electronic Lab Notebooks (ELN) and preparing technical reports and preclinical dossiers. Strong literature and database mining skills, particularly for safety data. Experience-or strong interest-in interpreting non-clinical safety and toxicology data. Familiarity with evaluating toxicology packages and identifying dose-limiting toxicities. Experience in oncology and/or neurology is advantageous. Values and Mindset Innovate and Deliver – Agile & Adaptive: Comfortable working in a fast-moving environment and adapting to new scientific opportunities. Grow as Individuals – Holistically Ambitious: Motivated to expand beyond a narrow specialism and influence broader drug discovery strategy. Care for Rare – AI-Curious & Patient-Centric: Excited by the intersection of biology and AI, with a strong focus on patient impact. Win as a Team – Collaborative & Growth-Oriented: Committed to learning, mentoring, and contributing to an inclusive team culture. Working at Healx Healx operates a hybrid working model, with a modern and accessible Cambridge office. For this role, we ideally ask for at least one day per week onsite. We offer flexible working arrangements, including part-time options, to support both individual needs and business goals. You’ll join a collaborative and supportive team with deep expertise, committed to helping you grow and succeed. We place a strong emphasis on personal development, ensuring you have the support and opportunities to advance your career while making a meaningful impact. What’s on offer Financial – Competitive salary, share options, 7% employer pension contributions, life insurance of 4x base salary. Health and Wellbeing – Private medical insurance, 25 days annual leave (plus bank holidays) with the option to purchase additional days to support a healthy work-life balance and wellbeing support. Hybrid Working – Flexible and remote working options, home office set-up allowance, periodic in-person team days for company-wide collaboration and celebration. Family Friendly – Enhanced family leave policies and flexible working practices. Happy to Talk Flexible Working – We follow the Working Families guidance for flexible working, and are open to exploring together how to make this role fit both the business and your needs. Personal Development and Growth – Personal learning and development budgets, regular personal development conversations and career support. Community Engagement and Support – Opportunities to engage with rare disease patient communities and gain insight into patient experiences. One paid volunteering day per year to support a cause aligned with our mission.