Sr. Network and Infrastructure Engineer

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California. Onsite: Monday, Tuesday & Thursday Summary: We are seeking a highly skilled and versatile Senior Network & Infrastructure Engineer to join our growing team. This role is designed for a technical "bridge" builder—someone who possesses deep expertise in high-performance networking (HPC) and Cisco security, but who is also comfortable managing a modern, hyperconverged infrastructure stack. The successful candidate will lead the architecture and maintenance of our Cisco Nexus fabric, secure our perimeter with NextGen firewalls, and support a robust environment consisting of VxRail, VMware, and petabyte-scale HPC storage. You will be equally at home in a CLI environment as you are performing hands-on hardware management within our colocation data centers. Responsibilities: Network & Security Architecture (60%) HPC Networking: Architect, deploy, and optimize Cisco Nexus switches within a High-Performance Computing (HPC) environment, ensuring low latency and high throughput. Security & Firewalls: Full lifecycle management of Cisco NextGen Firewalls (NGFW) . You must be proficient in configuring security policies, routing, and VLAN segmentation. VPN Management: Lead the setup and maintenance of VPN connections (Site-to-Site and Remote Access) on Cisco platforms. Circuit Operations: Oversee the provisioning, monitoring, and troubleshooting of network circuits and ISP handoffs. Cloud Connectivity: Act as a subject matter expert for hybrid-cloud networking, supporting connectivity between on-premise hardware and AWS/GCP (Direct Connect/Cloud Interconnect). Infrastructure & Systems Management (30%) Virtualization: Administer and scale VMware clusters running on Dell VxRail hyperconverged infrastructure. HPC Storage: Support high-performance storage environments, specifically VAST Data and Dell Isilon , ensuring data availability for intensive workloads. Systems Administration: Provide tier-3 support for Linux (RHEL/Ubuntu/CentOS) and Active Directory environments. Enterprise Tech: Manage Cisco Meraki wireless and edge networking for corporate office connectivity. Data Protection: Ensure the integrity of the environment through rigorous backup schedules and disaster recovery testing. Physical Operations  (10%) Data Center Ops: Perform hardware installations (Rack & Stack), cable management, and physical troubleshooting in Colocation (Colo) and Data Center environments. Requirements: Experience: 5–8+ years of hands-on experience in network engineering and infrastructure. Cisco Mastery: Advanced knowledge of Cisco Nexus (NX-OS) and Cisco NextGen Firewalls . Networking Fundamentals: Deep understanding of BGP, OSPF, VLANs, LACP, and VPN protocols (IPsec/SSL), WAN technologies. Hardware Knowledge: Proven experience with Dell server hardware and VxRail . Storage Proficiency: Exposure to high-performance file systems (VAST, Isilon). Physical: Ability to work on-site at data centers and office/labs, including lifting up to 50 lbs and working within server racks. Preferred "Plus" Skills: Cloud: Experience with AWS (VPC, Transit Gateway) or GCP (Cloud Router). Certifications: CCNP (Data Center/Security), VCP (VMware Certified Professional), or AWS Solutions Architect. Environment: Prior experience working in R&D, scientific, or lab environments. Automation: Experience with Python, Ansible, or Terraform for infrastructure-as-code. The hiring range for this position is $150,000 to $170,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered. Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you. Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @ personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community. Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.) #LI-KK1 #LI-Hybrid