Senior Vice President, Sales

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply. The Opportunity The SVP of Sales will play a critical leadership role in building and executing the commercial strategy for a pre‑commercial biotechnology company preparing for its first product launch. This individual will be responsible for designing and implementing the Go‑To‑Market (GTM) strategy, recruiting and developing a high‑performing sales organization, establishing strong relationships with Key Opinion Leaders (KOLs), ensuring full sales force readiness ahead of launch and driving performance. We anticipate hiring the Senior Vice President, Sales in September 2026. The ideal candidate combines strategic vision with hands‑on execution experience in specialty pharma or biotech launches and thrives in a fast‑paced, build‑from‑scratch environment. Responsibilities Enterprise Commercial Leadership Shape overall U.S. commercial strategy in partnership with the Chief Commercial Officer, including long-range planning beyond initial launch. Play a key role in portfolio planning and lifecycle strategy, including future indications and pipeline assets. Contribute to Board-level discussions on commercial readiness, launch strategy, and performance. Partner with Finance and Executive Leadership on revenue planning, scenario modeling, and investment decisions. Go‑To‑Market Strategy & Execution Design and implement a comprehensive Go‑To‑Market plan, aligned with brand strategy, market access, patient services, medical affairs, and marketing capabilities. Translate clinical value propositions into clear commercial messaging and field execution plans. Partner cross‑functionally with Marketing, Medical Affairs, Market Access, and Operations to ensure launch readiness. Define sales territory strategy, targeting, segmentation, and deployment models. Establish key performance indicators (KPIs), sales forecasting processes, and performance management frameworks. Sales Organization Build‑Out Recruit, hire, and onboard a high‑caliber field sales team, including regional leadership. Design and evolve a scalable sales organization architecture, with the ability to expand across multiple teams, regions, and future product lines. Develop a multi-year sales capability roadmap, including leadership bench building and succession planning. Build and lead second-line leadership (RSDs/Area Directors) as the organization scales. Develop and implement training programs to prepare the team for launch, including disease state education, product knowledge, and selling skills. Create a performance‑driven culture focused on accountability, collaboration, and continuous improvement. Launch Preparation & Excellence Lead all sales‑related launch readiness activities, ensuring the field team is fully prepared for pre-launch and launch execution. Oversee development and deployment of sales tools, CRM processes, call planning, incentive compensation and reporting infrastructure. Ensure compliance with all regulatory, legal, and ethical standards. KOL & External Engagement Engage with Key Opinion Leaders (KOLs) and other key stakeholders to support scientific exchange and commercial insight gathering. Partner with Medical Affairs to ensure appropriate, compliant KOL interactions. Provide field‑based insights to inform brand strategy, messaging refinement, and lifecycle planning. Leadership & Stakeholder Management Serve as a key member of the commercial leadership team, contributing to overall business strategy. Present sales strategy, progress, and performance updates to executive leadership and the Board as required. Mentor and develop future sales leaders within the organization. Required Qualifications Bachelor’s degree required; advanced degree (MBA, MS, PhD) preferred. 15+ years of progressive sales leadership experience in biotech or pharmaceutical organizations. Demonstrated success leading early product launches, ideally in specialty or rare disease. Proven experience building and scaling sales teams in pre‑commercial or early‑stage environments. Strong understanding of the U.S. healthcare landscape, including KOL engagement, payer dynamics, and integrated launch planning. Experience working cross‑functionally in highly matrixed organizations. Ability to operate both strategically and tactically in a resource‑constrained environment. Work Location and Conditions At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii Michigan and Tennessee. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity. Estimated Pay Range $353,000 — $397,000 USD To stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn . To return to our website please click here . Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.