Senior Medical Director - GI/GU

At Caris, we understand that cancer is an ugly word—a word no one wants to hear, but one that connects us all. That’s why we’re not just transforming cancer care—we’re changing lives. We introduced precision medicine to the world and built an industry around the idea that every patient deserves answers as unique as their DNA. Backed by cutting-edge molecular science and AI, we ask ourselves every day: “What would I do if this patient were my mom?” That question drives everything we do. But our mission doesn’t stop with cancer. We're pushing the frontiers of medicine and leading a revolution in healthcare—driven by innovation, compassion, and purpose. Join us in our mission to improve the human condition across multiple diseases. If you're passionate about meaningful work and want to be part of something bigger than yourself, Caris is where your impact begins. Position Summary Caris is seeking a board-certified expert in Medical Oncology with deep experience in GI/GU malignancies to join our Medical Affairs team as Senior Medical Director, GI/GU. Reporting to the Senior Vice President of Medical Affairs and Chair of the Precision Oncology Alliance (POA), this individual will serve as a key strategic leader, scientific ambassador, and external face of Caris’ precision oncology platform. The Senior Medical Director will blend clinical expertise, scientific credibility, and communication excellence to educate and inspire oncologists, researchers, and healthcare stakeholders worldwide—highlighting the transformative potential of Caris molecular. Job Responsibilities Serve as the senior clinical and scientific voice for Caris in GI/GU oncology, representing the company at national and international meetings, academic institutions, and major cancer centers. Deliver high-impact public and scientific presentations to clinicians, researchers, and thought leaders, translating complex genomic science into clear, clinically relevant insights. Cultivate and maintain strategic relationships with key opinion leaders (KOLs), clinical collaborators, and POA member institutions to advance the Caris mission and strengthen brand leadership in precision oncology. Partner with internal stakeholders across R&D, Medical Affairs, Commercial, Business Development, and Marketing to ensure clinical accuracy, alignment, and innovation in messaging and product positioning. Advise on clinical strategy and evidence generation to support Caris’ growing presence in GI/GU oncology, including input on prospective trials, retrospective analyses, and real-world data initiatives. Contribute thought leadership to Caris’ scientific communications—advisory boards, symposia, webinars, publications, and slide decks that convey Caris’ scientific differentiation. Provide clinical mentorship to field-based medical personnel (e.g., Medical Science Liaisons), enhancing their effectiveness in customer engagement and scientific storytelling. Collaborate on content development for GI/GU oncology education programs, internal trainings, and professional/continuing medical education (CME) initiatives. Bridge insights from the field to internal teams, ensuring the evolving needs of GI/GU oncologists and researchers inform product innovation and R&D priorities. Required Qualifications MD or DO, board-certified in Medical Oncology (and/or Internal Medicine) with significant clinical experience in GI/GU oncology. Minimum of 3 years of recent clinical practice managing patients with solid tumors, with focused expertise in GI/GU malignancies. Proven excellence in scientific communication, public speaking, and KOL engagement at major oncology forums or academic settings. Demonstrated leadership in translating clinical and molecular insights into actionable strategies that advance product adoption or inform evidence generation. Strong executive presence, interpersonal skills, and ability to influence across scientific, clinical, and commercial domains. Proficient in Microsoft Office Suite, specifically Word, Excel, Outlook, and general working knowledge of Internet for business use. Preferred Qualifications Advanced understanding of molecular profiling, targeted therapies, and immunotherapy in GI/GU oncology. At least 3 years of experience in a senior Medical Affairs, Medical Director, or equivalent role within biotech, diagnostics, or pharmaceutical settings. Experience developing scientific education, publications, or clinical collaborations across multi-institutional networks. Established relationships with academic GI/GU oncologists and professional societies (IASLC, ASCO, ESMO, AACR, etc.). Physical Demands Must be comfortable with frequent travel (domestic and international), including evenings and weekends as required by business needs. Physical demands include typical office activities (sitting, using standard equipment, lifting routine office supplies). Training All job specific, safety, and compliance training are assigned based on the job functions associated with this employee. Annual Hiring Range $320,000 - $360,000 Actual compensation offer to candidate may vary from posted hiring range based upon geographic location, work experience, education, and/or skill level. The pay ratio between base pay and target incentive (if applicable) will be finalized at offer. Description of Benefits Highly competitive and inclusive medical, dental and vision coverage options Health Savings Account for medical expenses and dependent care expenses Flexible Spending Account to pay for certain out-of-pocket expenses Paid time off, including: vacation, sick time and holidays 401k match and Financial Planning tools LTD and STD insurance coverages, as well as voluntary benefit options Employee Assistance Program Pet Insurance Legal Assistance Tuition Assistance Conditions of Employment: Individual must successfully complete pre-employment process, which includes criminal background check, drug screening, credit check ( applicable for certain positions ) and reference verification. This job description reflects management’s assignment of essential functions. Nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time. Caris Life Sciences is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, gender, gender identity, sexual orientation, age, status as a protected veteran, among other things, or status as a qualified individual with disability.