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Sequencing.com is a profitable, Series A company at the intersection of biotech, genomics, and personalized health. As the world’s largest direct-to-consumer genomics platform, our mission is to power the future of personalized health by making whole genome sequencing and interpretation accessible, actionable, and meaningful for everyone. We partner with healthcare professionals, research organizations, and consumer wellness platforms to deliver deep genomic insights through our advanced data and bioinformatics platform. We are venture-backed, rapidly scaling, and assembling a team that is excited to build products that change the world. The Position The AI Bioinformatics Engineering Lead will sit within the AI team and collaborate closely with backend engineering, bioinformatics, and product leaders to shape how genomic data is evaluated and validated. Your success will be measured by robust evaluation and benchmarking strategies, clear accuracy thresholds, and production releases that consistently meet predefined correctness standards over time. The Impact Own gene, disease, and variant mapping logic in the AI system. Design and maintain how genomic data is used and interpreted in AI workflows. Define approaches for handling complex and edge-case genomic scenarios. Set measurable accuracy thresholds for AI-powered features. Define release criteria that AI features must meet before going live. Lead the overall evaluation and benchmarking strategy for AI outputs. Establish regression standards so future changes preserve or improve accuracy. Partner with the AI Bioinformatics Benchmarking Engineer on automated validation. Approve validation criteria that determine when AI features are ready for release. Work closely with AI, Bioinformatics, Product, and Engineering leaders on system design. Recommend where deterministic logic should supplement model behavior in production. Ensure interpretation logic can be maintained and updated as new genomic knowledge appears. Dominant and Recessive Traits Advanced degree in Bioinformatics, Computational Biology, or a closely related field. Strong experience with VCFs and complex genomic datasets. Familiarity with ClinVar, dbSNP, HGVS standards, transcript databases, and variant classification. Systems-level leadership that defines standards and frameworks for correctness. Experience working with production software engineering teams. Experience collaborating with AI or LLM-based systems. Experience setting or contributing to evaluation and benchmarking frameworks. Comfortable working fully remote as part of a distributed team. Benefits Overview We offer a comprehensive benefits package, including: Health, Vision, and Dental, Life Insurance 401(k) with Company Matching Fully Remote Work Paid Time Off Volunteer Time Off (paid time off for volunteering at non-profit or equivalent) Parental Bonding Time Short-Term Disability Insurance Remote Work Reimbursements (equipment, cellular, wifi, office supplies, etc.) Weekly paydays (every Friday) Genome sequencing for you and your immediate family (private and confidential) Sequencing Inc. is an equal opportunity employer. All aspects of employment, including the decision to hire, promote, discipline, or discharge, will be based on merit, competence, performance, and business needs. We do not discriminate based on race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law. Sequencing Inc. may use artificial intelligence (AI) or automated tools as part of the recruiting and hiring process, including for application screening and candidate evaluation. These tools may analyze information provided in your application materials or during the hiring process. Where required by applicable law, candidates may request a reasonable accommodation or an alternative selection process by contacting [email protected] .